Jojo’s Hirohiko Araki Illustrates Cell Cover
An illustration by Jojo’s Bizarre Adventure mangaka Hirohiko Araki dominates the cover of the current issue (Volume 130, Issue 3) of Cell Magazine. The American biweekly scientific journal publication focuses on exceptional research articles in areas including molecular biology, biochemistry, cancer research and cell biology. The issue is publicly available on September 7th. The cover image shows a character like that of an ESP powered member of Stand in Jojo’s stories destroying a harmful protein. From Cell’s own description: On the cover: Presynaptic plasticity is a fundamental, yet poorly understood, a neural phenomenon that is thought to be the basis of learning and memory. In this issue, Yao et al. (pp. 943?957) identify a novel ubiquitin ligase named SCRAPPER, which is responsible for tuning of synaptic vesicle release probability. SCRAPPER ubiquitinates presynaptic active zone protein RIM1, triggering its proteasomal degradation. Neurons from the Scrapper-knockout mice have hyper electrophysiological activity and contained an increased amount of RIM1, and these phenotypes could be rescued by re-expression of SCRAPPER or knockdown of RIM1. The results highlight the importance of protein degradation in the regulation of synaptic activity in vivo. On the cover, the purple SCRAPPER humanoid is putting blue heart-shaped ubiquitins on the red RIM creatures. Japanese manga artist Hirohiko Araki created the cover image with scientific direction from Drs. Setou and Ageta.